Modern scientific advances in Neuroscience and Artificial Intelligence are raising many questions for theologians, philosophers and scientists. What was previously thought to be mysterious and non-reproducible is being replicated and explained via neural circuitry and mechanical processes. This has led to the advent of a radically new ontology of the world, being advocated by certain modern-day thinkers, which denies metaphysical entities and properties. The claim by proponents of this view known as physicalism argue that, “we are nothing but our brains” and this view is directly opposed by various religious ontologies. This presentation will discuss how the topic of human nature was approached and delivered through the lenses of bioscience and Islam, and how we navigated the complexities and opportunities of teaching this ‘controversial’ topic across two different geographical and socio-cultural contexts. Classroom exercises included comparing and contrasting concepts of soul and consciousness from the perspectives of Islam vs. Neuroscientific Reductionism and engaging in several thought experiments. The session concluded with exploring how tensions may be overcome to have a level dialogue on topics in philosophy of mind across various philosophical and religious traditions.